Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. * Covers a wide range of topics in a systematic manner with an emphasis on industrial applications * Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering * Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs * Highlights the impact of biocatalysis on green chemistry * Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

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Wiley-VCH GmbH
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Dr. Junhua Tao is co-founder and Chief Scientific Officer at BioVerdant, Inc.USA. He was the Head of the Biotransformation Group at Pfizer Global R&D from 2000 to 2005. Trained in synthetic organic chemistry, Dr. Tao has published over 50 papers and serve as an advisory board member of Engineering in Life Sciences Prof. Guo-Qiang Lin is a professor at Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, China. With over 150 publications, Prof. Lin is well recognized in synthetic organic chemistry and medicinal chemistry. He is associate editors for three journals in the fields and an Executive Board Member for Tetrahedron. Prof. Andreas Liese is Professor of Technical Biochemistry and Head of Institute of Technical Biocatalysis, Hamburg University of Technology, Germany. Worked in both academia and pharmaceutical industry, Prof. Liese has made significant contributions to industrial biotransformations, enzyme technology and biochemical engineering. He is a member of the editorial board, Journal of Molecular Catalysis B and has published over 50 papers and 2 books.

Leseprobe

1. Enzymes and Their Synthetic Applications: An Overview 2. Expression Hosts for Enzyme Discovery and Production 3. Directed Enzyme Evolution and High Throughput Screening 4. Applications of Reaction Engineering to Industrial Biotransformations 5. Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases 6. Expanding the Scope of Aldolases as Tools for Organic Synthesis 7. Synthetic Applications of Ketoreductases and Alcohol Oxidases 8. Applications of Nitrile Hydratases and Nitrilases 9. Biosynthesis of Drug Metabolites 10. Application of Whole Cell Biotransformation in Pharmaceutical Industry 11. Combinatorial Biosynthesis of Pharmaceutical Natural Products 12. Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals 13. Multimodular Synthases and Supporting Enzymes for Chemical Production 14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals