Part of Springer¿s ''The Receptors,a¿ series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors¿ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson¿s disease, Prader-Willi Syndrome, Alzheimer¿s disease and epilepsy.

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Chapter 1The making of the 5-HT2C receptor Jose M. Palacios, Angel Pazos and Daniel Hoyer Chapter 2Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brain Guadalupe Mengod Chapter 3The medicinal chemistry of 5-HT2C receptor ligands Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Francesco Berardi, Roberto Perrone Chapter 4Insights into 5-HT2C receptor function gained from transgenic mouse models Stephen J. Bonasera Chapter 5Serotonin 5-HT2C receptor signal transduction Maria N. Garnovskaya and John R. Raymond Chapter 6Homology modeling of 5-HT2C receptors Nicolas Renault, Amaury Farce, Philippe Chavatte Chapter 75-HT2C receptor dimerization Katharine Herrick-Davis and Dinah T. Farrington Chapter 8RNA editing of 5-HT2C receptor and neuropsychiatric diseases Kazuya Iwamoto, Miki Bundo and Tadafumi Kato Chapter 9Serotonergic control of adult neurogenesis: focus on 5-HT2C receptors Annie Daszuta Chapter 10The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system Sylvia Navailles, Philippe De Deurwaerdere Chapter 11The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studies Giuseppe Di Giovanni, Ennio Esposito and Vincenzo Di Matteo Chapter 12The role of serotonin-2C receptors in the pathophysiology of depression Eliyahu Dremencov, Joost HA Folgering, Sandra Hogg, Laurence Tecott and Thomas I.F.H. Cremers Chapter 135-HT2C receptors and suicidal behaviour Fabio Panariello, Naima Javaid and Vincenzo De Luca Chapter 14The 5-HT2C receptor as a target for schizophrenia Herbert Y Meltzer, Liwen Sun and Hitoshi Hashimoto Chapter 15Serotonin and reward-related behaviour: focus on 5-HT2C receptors Paul J. Fletcher and Guy A. Higgins Chapter 16Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptor Amy Hu, Lintao Jia, Jean-Christian Maillet, Xia Zhang Chapter 17The role of serotonin in eating behaviour: focus on 5-HT2C receptors Jason C.G. Halford Chapter 18Physiological and pathophysiological aspects of 5-HT2C receptors in basal ganglia Philippe De Deurwaerdere, Laurence Mignon and Marie-Francoise Chesselet Chapter 19Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment Richard M. Kostrzewa Chapter 20The role of 5-HT2A/2C receptors in sleep and waking Jaime M. Monti and Hector Jantos Chapter 21Role of alternative splicing of the 5-HT2C in the Prader-Willi syndrome Shivendra Kishore and Stefan Stamm Chapter 22The role of 5-HT2C receptor in epilepsy Rita Jakus and Gyorgy Bagdy Chapter 23The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptors Eleftheria Tsaltas and Vasileios Boulougouris Chapter 245-HT2C receptors in learning Lopez-Vazquez Miguel Ángel, Gutierrez-Guzman Blanca Erika, Cervantes Miguel and Olvera-Cortes María Esther Chapter 25The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer''s disease Antonia Pritchard Chapter 26Ocular hypotension: involvement of serotonergic 5-HT2C receptors Najam A. Sharif