Filling a gap in the market, this two-volume set is the first to present important pharmaceuticals as well as agrochemical pesticides in one handy work. Each of the around 40 chapters covers in a concise manner one class of heterocycles, clearly structured as follows: * Structural formulas of most important examples (market products) * Short background of history or discovery * Typical syntheses of important examples * Mode of action * Characteristic biological activity * Structureactivity relationship * Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.) * References. A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the field of pharmaceutical and agrochemical chemistry.

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Wiley-VCH GmbH
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DE 69469 Weinheim

InhaltsangabeAGROCHEMICALS THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS Introduction Heterocycles as Framework of Biologically Active Compounds FineTuning the Physicochemical Properties with Heterocycles Heterocycles as Prodrugs Heterocycles as Peptidomimetics Heterocycles as Isosteric Replacement of Functional Groups Heterocycles as Isosteric Replacement of Alicyclic Rings Heterocycles as Isosteric Replacement of other Heterocyclic Rings PART I: Herbicides TRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship HPPDINHIBITING BENZOYLPYRAZOLE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COACARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationships IMIDAZOLINONE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PART II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PHENYLPYRROLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship BROADSPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationships PART III: Insecticides AVERMECTIN INSECTICIDES AND ACARICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationship PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR Introduction History Synthesis Mode of Action Biological Activity Structure Activity Relationships TETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COACARBOXYLASE Introduction History Synthesis Mode of Action Biological