InhaltsangabeForeword.- GH and IGF1: Aspects of Global and Local Release and Actions.- Hyperglycemia Regulates the Sensitivity of Vascular Cells to IGF-I Stimulation.- IGFBP2 Supports ex Vivo Expansion of Hematopoietic Stem Cells.- The Role of Insulin-like Growth Factor-I in Central Nervous System Development.- Stimulation of Proliferative Pathways by IGF-binding Proteins.- Gene Activities that Mediate Increased Lifespan.- IGF1 Regulation of Skeletal Muscle Hypertrophy and Atrophy.- Growth Hormone, Insulin-like Growth Factor-I and Insulin: their Relationship to Aging and Cancer.- The Functions of Insulin-like Peptides in Insects.- IGF Receptors in the Adult Brain.- The Role of the IGF-1 and its Partners in Central and Peripheral Metabolism: Considerations for Extending Healthy Life Span.- Subject Index.